What Is VIVOTIF1?

VIVOTIF is indicated for active oral immunisation against typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), in adults and children aged five years and older.

This vaccine should be used in accordance with official recommendations.

VIVOTIF works in three ways

VIVOTIF protects against Salmonella Typhi by mimicking the response to natural infection and stimulating local, cellular and systemic/humoral immunity 2-5

  1. Local immune response: IgA
  2. Cellular mediated immunity:
    macrophages/cytotoxic T lymphocytes
  3. Systemic/humoral immune responses: IgG

Three year Protective Efficacy
Demonstrated in Clinical Studies

The protective efficacy of VIVOTIF was demonstrated in several large-scale field trials
involving more than 500,000 subjects2

Randomised, placebo-controlled study in an endemic population (Chile)

Established Safety Profile1

VIVOTIF is generally well tolerated with a low incidence of adverse events.

Reporting Adverse Events
Adverse events should be reported to Emergent at medicalinformation@ebsi.com

How is VIVOTIF reconstituted and administered?

1 capsule taken on Days 1, 3, and 5 may provide up to 3 years of protection against typhoid fever.

Complete vaccination is comprised of the ingestion of three capsules. Optimal immune response may not be achieved unless the entire vaccination schedule is completed.

Revaccination is recommended at three years following the most recent vaccination for all individuals.

  • Oral administration with 3 capsules over 5 days, each to be taken approximately 1 hour before a meal with cold or lukewarm water
  • Protection achieved 7-10 days after the last dose for adults and children aged 5 years and over
  • Refrigerate at 2°C – 8°C

In the case of travel from a non-endemic area to an area where typhoid is endemic, Green Book recommends a booster consisting of the 3 doses of VIVOTIF be administered every 3 years6

VIVOTIF is supplied in a single foil blister containing 3 doses of vaccine in a single package.

VIVOTIF, Salmonella enterica serovar Typhi
Legal category: POM Basic NHS


Storage and Handling:

  • - VIVOTIF should be stored between 2°C and 8°C.
  • - Keep the blister pack within the outer carton to store away from light.

Cost: £14.17

Order now

For medical enquiries, please contact Medical Information at 0800 088 5449

Resources for HCP

For HCP

All About VIVOTIF

Download

For HCP

VIVOTIF Packaging Leaflet

Download

For HCP

VIVOTIF SmPC

Go to link

For HCP

Authorization for Patient Specific Direction (PSD) of VIVOTIF

Download

For HCP

Authorization for Patient Group Direction (PGD) of VIVOTIF

Download

For HCP

VIVOTIF Outer Packaging

Order

Resources for Patients

For HCP

Patient Brochure

Download

For HCP

How to Take VIVOTIF

Order

Text Message Reminder Service

Free text message
reminders to help patients
stay on course with VIVOTIF.

Text vivo to 80800
References.
  1. VIVOTIF® Summary of Product Characteristics.
  2. Guzman CA, et al. Vaccine. 2006;24:3804-3811.
  3. Dietrich G, et al. Vaccine. 2003;21:678-683.
 
  1. Salerno-Goncalves R, et al. J Immunol. 2002;169:2196-2203.
  2. Sztein MB. Clin Infect Dis. 2007;45:S15-S19.
  3. The Green Book. Chapter 33: Typhoid. https://www.gov.uk/government/publications/typhoid-the-green-book-chapter-33. Accessed October 10, 2019.
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